Endocrine Abstracts

Aim: The aim of this study is to correlate the histopathological cell types and morphologic features of parathyroid neoplasms with ultrasound(US) images and laboratory findings, and also gain more information about the clinical importance of these results.Materials and methods: The parathyroid lesions of 57 patients who were operated for hyperparathyroidism were sampled on saggital plane. The slides were scanned on high resolution and digital whole slide...

Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia and characterized with autoantibodies to insulin in a patient without prior exposure to exogenous insulin. Medications with sulfydryl group and autoimmune diseases are known to be associated with this syndrome. Nearly 90% of the cases were reported in Japanese patients. We presented a Turkish patient with insülin autoimmune syndrome possibly caused by α-lipoic acid. A 62-year-old woman was admitted to ...

Introduction: This study was designed to determine whether obesity causes inflammation on both conjunctival epithelium cells as well as on squamous metaplasia.Materials and methods: Around 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of them, nearly 20 were obese, and 41 were of normal weight. We measured the glucose and insulin values for all volunteers. We also measured the Body Mass Index (B...

Androgenic alopecia (AGA) is an important clinical issue that can cause significant cosmetic problems. Many factors such as genetic, androgen hormones, environmental factors, and inflammation are involved in the pathogenesis of androgenic alopecia. Insulin and insulin resistance have been found increased in individuals with AGA. There are many proinflammatory substances which are playing role in the pathogenesis of androgenic alopecia. Secreted frizzled related protein-4 (SFRP...

Introduction: Malignant insulinoma is a rare functional endocrine tumor of the pancreas. Therefore, there are few data regarding their optimal therapy and long term prognosis. Malignancy is defined by the presence of metastases, mostly in lymph nodes or the liver. Generally these patients present with severe hypoglycemia and require multiple therapies. Here, we described the management of a patient with malignant insulinoma.Case: A 41-year-old woman with...

ObjectiveThere is limited clinical data available on bilateral adrenal masses (BAM). Here we present a case with BAC and adrenal insufficiency. The patient’s lesions disappeared after steroids, re-grew in the follow-up, allowing a biopsy.CaseA 60-year-old male patient presented with abdominal pain, nausea, and weakness to another hospital. Hyponatremia and hyperkalemia accompanied by hypotension were det...

IntroductionThe most common causes of pseudo Cushing syndrome are alcoholism, chronic kidney disease, neuropsychiatric diseases, pregnancy, uncontrolled diabetes, and drugs. We present a patient who was operated on suspected Cushing syndrome based on abnormal results in overnight dexamethasone suppression tests.Case presentationA 49-year-old female patient was referred to our clinic for reoperation due to per...

Context: The impact of abnormal cortisol secretion on cognitive functions in patients with mild autonomous cortisol secretion (MACS) remains uncertain.Objective: To assess cognitive functions, determine serum brain-derived neurotrophic factor (BDNF) concentration in patients with MACS, and investigate the possible association between cognitive subdomains and BDNF after minimizing the impact of body mass index (BMI) and visceral adiposity.<p class="ab...

Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones secreted from enteroendocrine L cells following a meal that play a key role in regulating insulin secretion and glucose metabolism. Enteroendocrine L cells express calcium-sensing receptors (CaSRs), which serve as a physiological nutrient sensor for the release of hormones from the gastrointestinal tract. While calcium is the primary ligand for CaSR, its activity can also be controlled by amino acids and polyami...

Objective: Even with advancements in diagnostic techniques, acromegaly continues to be diagnosed late. This study aimed to employ deep learning methods to automatically identify acromegaly disease from images of faces, hands, and feet to enhance the efficiency of disease detection.Design: Cross-sectionaly single-center study with deep learningMethods: The study included 71 acromegaly patients and 65 healthy controls. All patients h...